BioCytoceuticals - Neurodegeneration Diseases

Neurodegeneration is a feature of many debilitating, incurable diseases that are rapidly rising in prevalence, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, frontotemporal dementia and the spinocerebellar ataxias. There is an urgent need to develop new and more effective therapeutic strategies to combat these devastating diseases. Models – from cell-based systems, to unicellular organisms, to complex animals – have proven to be a useful tool to help the research community shed light on the mechanisms underlying neurodegenerative diseases, and these advances have now begun to provide promising therapeutic avenues.

Alkaline phosphatase: a novel treatment target

Neurodegenerative diseases are diverse in their pathophysiology. Therefore, effective treatments are desperately needed but will only come with a deep understanding of the causes and mechanisms of each disease.

New hope for models, mechanisms and more

The more recently acquired ability to generate induced-pluripotent stem cells (iPSCs) from differentiated human cells has made it possible to generate patient-specific cell lines in a tissue culture dish – generating human models of human disease.
There have been technological innovations that allow for patient-specific cells to be cultured in 3D. These 3D brain organoid systems permit cell-cell interactions and complex cyto-architecture to be modeled and studied in greater detail and in more physiological contexts than traditional tissue culture models with isolated cells.
Accruing evidence suggests that many neurodegenerative diseases are not merely diseases of dying neurons. Non-neuronal cells in the brain, such as glial cells, which are even more abundant in the brain and the central nervous system than neurons, play major roles in disease progression.

Comprehensive characterization services for disease-specific models are also provided.

Comprehensive characterization services for disease-specific models Cx43 expression is inherently elevated in mouse SOD1 G93A astrocytes and ALS human iPSC-derived astrocytes.

BioCytoceuticals leads the industry in cellular therapy with commitment to providing the most appropriate solutions to address the needs of our clients. Our expert team of scientists applies comprehensive methods and most detail-oriented scrutiny to ensure only top-tier outcome is submitted.

If you have any special enquiries regarding our Neurodegeneration diseases models service, please do not hesitate to contact us. Our highly professional technical supporting staffs will make sure your requests are faithfully received. We are looking forward to earning your business.

For research use only. Not for any other purpose.

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