BioCytoceuticals - Liver Diseases

Liver is a key organ in drug testing, in which it is used to assess the pharmacokinetics and toxicology of xenobiotics, but the results obtained in animal models are often misleading, due to differences in the levels and substrate specificity of liver enzymes between animals and humans. Consequently, the hepatic clearance and chemical profiles obtained for metabolites in animal models do not correctly represent what is observed in humans.

All these limitations to direct therapeutic applications and drug discovery have highlighted the need to explore other sources of cells. Stem cells that could be isolated, expanded to yield sufficiently large clonal populations and then induced to differentiate into fully functional hepatocytes in vitro would be an ideal source of cells.

Generation of hepatocytes and cholangiocytes from human‐induced pluripotent stem cells.

Human Stem cells, especially iPSCs in terms of their self-renewal capacity and ability to differentiate into cell types are derived from the three primary germ layers.

Stem cells provide a unique opportunity to study patient-specific diseases, once the conditions required to induce their differentiation into the desired type of cell have been defined. This is particularly important for patients with liver diseases, who cannot undergo surgical biopsy for the isolation of hepatocytes for transplantation.
iPSC technology should make it possible to identify the impact of mutations on the differentiation/proliferation/function of the cells. Patients’ iPSCs should also be good tools for the screening of candidate pharmacological molecules.

Alkaline phosphatase: a novel treatment target Characterization of hepatocyte-like cells (HLCs) derived from hemophilia B (HB)-16 and HB-28 induced pluripotent stem cell (iPSC) clones.

Comprehensive characterization services for disease-specific models are provided by BioCytoceuticals.

BioCytoceuticals leads the industry in cellular therapy with commitment to providing the most appropriate solutions to address the needs of our clients. Our expert team of scientists applies comprehensive methods and most detail-oriented scrutiny to ensure only top-tier outcome is submitted.

If you have any special enquiries regarding our Liver Diseases models service, please do not hesitate to contact us. Our highly professional technical supporting staffs will make sure your requests are faithfully received. We are looking forward to earning your business.

For research use only. Not for any other purpose.

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